Omega-3 fatty acids and vitamin D supplements found to slow aging
Research results on the health effects of taking certain nutrients and supplements are mixed, with
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial | Nature Aging
https://www.nature.com/articles/s43587-024-00793-y
Daily omega-3 fatty acids may help human organs stay young
https://medicalxpress.com/news/2025-02-daily-omega-fatty-acids-human.html
An omega-3 dose a day could slow aging process, 'healthspan' trial finds | Ageing | The Guardian
https://www.theguardian.com/science/2025/feb/03/an-omega-3-dose-a-day-could-slow-ageing-process-healthspan-trial-finds
In a paper published in the online-only journal Nature Aging on February 3, 2025, a research team led by Heike Bischoff-Ferrari of the University of Zurich in Switzerland announced the results of a clinical trial targeting Swiss elderly people aged 70 years or older.
The study first looked at 1,006 Swiss participants from the DO-HEALTH study, which is investigating the effects of omega-3 fatty acids and vitamin D on the health of older Europeans, and divided 777 of them into eight groups who agreed to have their DNA analysed.
We conducted a randomized, double-blind, placebo-controlled trial with a 2 × 2 × 2 factorial design in which participants were assigned to one of three trials: 1 g of omega-3 fatty acids per day (EPA 330 mg + DHA 660 mg) versus placebo; 2,000 IU of vitamin D per day versus placebo; 30 minutes of strength training or flexibility exercises three times a week; or a combination of these three trials.
The participants' aging was also quantified using a technique called the '
The study found that older adults who consumed omega-3 fatty acids for three years had a biological age that was about three months younger than those who did not, based on three different epigenetic clocks. In one of the three studies, the effect was extended to about four months when omega-3 fatty acids were combined with vitamin D and exercise.
'While a reduction in biological age by three to four months over a three-year period may seem like a small effect, if continued, it could have a significant impact on the health of society as a whole,' Bischoff-Ferrari said.
The entire DO-HEALTH study, which did not include DNA analysis, also confirmed that essential fatty acids and vitamins are important for
According to a paper published by Bischoff-Ferrari et al. in 2022, taking omega-3 fatty acids reduced infections by 13% and falls by 10%. In addition, three interventions combining vitamin D and strength training were reported to reduce the risk of pre-frailty, a stage before frailty in which elderly people are at high risk of becoming dependent on care, by 39% and the development of invasive cancer by 61%.
'These findings reinforce my commitment to taking low doses of omega-3 fatty acids and vitamin D, exercising regularly, and doing everything in moderation,' said study co-author Steve Horvath of the biotechnology company Altos Labs.
Omega-3 fatty acids and vitamin D supplements are easily available at pharmacies and on Amazon.co.jp.
Amazon | Otsuka Pharmaceutical Nature Made Super Fish Oil (EPA/DHA) 90 tablets [Functional Food (Ingredient Evaluation)] 90-day supply | NATUREMADE | Multi-fatty acids
Amazon | Dear Natura Vitamin D 60 tablets (60 days' worth) | Dear Natura | Vitamin D
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